Cognitive subtypes of probable Alzheimer?s disease

 
   Lead Investigator:    Diane Jacobs
   Institution      :    UC San Diego Shiley-Marcos ADRC
   E-Mail           :    djacobs@ucsd.edu
   Proposal ID      :    980


   Publications:


1  Qiu Y, Jacobs D, Messer K, Salmon D, Feldman H
   Cognitive Heterogeneity in Probable Alzheimer's Disease: Clinical and Neuropathological Features
   2019   Journal Article  Neurology   epub ahead of p   ,PMC in process

   PUBLISHED





   Proposal Description:
   We have previously identified cognitive subtypes among patients with mild-to-moderate AD using principal component and cluster analyses of data from version 3 of the UDS neuropsychological test battery. Here we aim to   1) Replicate the principal component and cluster analyses using data from version 2 of the UDS neuropsychological test battery  2) Compare longitudinal rates of change between cognitive subtypes, identified by cluster analysis  3) Examine associations between cognitive subtype and imaging findings CSF biomarkers, when available  4) Examine associations between cognitive subtype and neuropathological findings, when available. Identifying and characterizing cognitive subtypes of probable AD will help to elucidate heterogeneity in the symptomatology and course of AD, therein potentially improving clinical care and trial design.